Reconstructing solid state nanopore shape from electrical measurements

Yael Liebes; Maria Drozdov; Yotam Y. Avital; Yaron Kauffmann; Hanna Rapaport; Wayne D. Kaplan; Nurit Ashkenasy

doi:10.1063/1.3521411

Reconstructing solid state nanopore shape from electrical measurements

Yael Liebes, Maria Drozdov, Yotam Y. Avital, Yaron Kauffmann, Hanna Rapaport, Wayne D. Kaplan, Nurit Ashkenasy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The dependence of nanopore biosensor conductance signal on the nanopore shape makes it important to decipher the latter with high precision. We show here that the three dimensional shape of a nanopore, extracted from electron microscopy analysis, allows for modeling the conductance of the nanopore over a wide range of ionic strengths. Furthermore, we demonstrate that the dependence of the nanopore conductance on ionic strength can be used to accurately extract the nanopore shape, eliminating the need for lengthy electron microscopy analysis. The suggested methodology can be used to monitor changes in the nanopore shape and evaluate them during electrical characterization.

Original language	English
Article number	223105
Journal	Applied Physics Letters
Volume	97
Issue number	22
DOIs	https://doi.org/10.1063/1.3521411
State	Published - 29 Nov 2010

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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title = "Reconstructing solid state nanopore shape from electrical measurements",

abstract = "The dependence of nanopore biosensor conductance signal on the nanopore shape makes it important to decipher the latter with high precision. We show here that the three dimensional shape of a nanopore, extracted from electron microscopy analysis, allows for modeling the conductance of the nanopore over a wide range of ionic strengths. Furthermore, we demonstrate that the dependence of the nanopore conductance on ionic strength can be used to accurately extract the nanopore shape, eliminating the need for lengthy electron microscopy analysis. The suggested methodology can be used to monitor changes in the nanopore shape and evaluate them during electrical characterization.",

author = "Yael Liebes and Maria Drozdov and Avital, {Yotam Y.} and Yaron Kauffmann and Hanna Rapaport and Kaplan, {Wayne D.} and Nurit Ashkenasy",

note = "Funding Information: This work was supported by a joint Technion-BGU Nevet program and an Israel Science Foundation Converging Technologies grant (Grant No. 1717/07). Y.L. was supported by a Hanegev scholarship and M.D. by a Russell Berrie Nanotechnology Institute scholarship.",

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AU - Liebes, Yael

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AU - Avital, Yotam Y.

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AU - Rapaport, Hanna

AU - Kaplan, Wayne D.

AU - Ashkenasy, Nurit

N1 - Funding Information: This work was supported by a joint Technion-BGU Nevet program and an Israel Science Foundation Converging Technologies grant (Grant No. 1717/07). Y.L. was supported by a Hanegev scholarship and M.D. by a Russell Berrie Nanotechnology Institute scholarship.

PY - 2010/11/29

Y1 - 2010/11/29

N2 - The dependence of nanopore biosensor conductance signal on the nanopore shape makes it important to decipher the latter with high precision. We show here that the three dimensional shape of a nanopore, extracted from electron microscopy analysis, allows for modeling the conductance of the nanopore over a wide range of ionic strengths. Furthermore, we demonstrate that the dependence of the nanopore conductance on ionic strength can be used to accurately extract the nanopore shape, eliminating the need for lengthy electron microscopy analysis. The suggested methodology can be used to monitor changes in the nanopore shape and evaluate them during electrical characterization.

AB - The dependence of nanopore biosensor conductance signal on the nanopore shape makes it important to decipher the latter with high precision. We show here that the three dimensional shape of a nanopore, extracted from electron microscopy analysis, allows for modeling the conductance of the nanopore over a wide range of ionic strengths. Furthermore, we demonstrate that the dependence of the nanopore conductance on ionic strength can be used to accurately extract the nanopore shape, eliminating the need for lengthy electron microscopy analysis. The suggested methodology can be used to monitor changes in the nanopore shape and evaluate them during electrical characterization.

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Reconstructing solid state nanopore shape from electrical measurements

Abstract

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