Reconstructing solid state nanopore shape from electrical measurements

Yael Liebes, Maria Drozdov, Yotam Y. Avital, Yaron Kauffmann, Hanna Rapaport, Wayne D. Kaplan, Nurit Ashkenasy

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The dependence of nanopore biosensor conductance signal on the nanopore shape makes it important to decipher the latter with high precision. We show here that the three dimensional shape of a nanopore, extracted from electron microscopy analysis, allows for modeling the conductance of the nanopore over a wide range of ionic strengths. Furthermore, we demonstrate that the dependence of the nanopore conductance on ionic strength can be used to accurately extract the nanopore shape, eliminating the need for lengthy electron microscopy analysis. The suggested methodology can be used to monitor changes in the nanopore shape and evaluate them during electrical characterization.

Original languageEnglish
Article number223105
JournalApplied Physics Letters
Volume97
Issue number22
DOIs
StatePublished - 29 Nov 2010

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