Recurrence of Preterm Delivery in Women with a Family History of Preterm Delivery

Yehonatan Sherf, Eyal Sheiner, Ilana Shoham Vardi, Ruslan Sergienko, Jamie Klein, Natalya Bilenko

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective This study aims to evaluate the role of a family history of preterm delivery on the risk of preterm delivery in the next generation. Study Design A retrospective population-based study was conducted. Perinatal information was gathered from 2,303 familial triads, composed of mothers (F1), daughters (F2), and children (F3). All births occurred in the same regional medical center between the years 1991 and 2013. Statistical analysis using logistic regression was performed to define the risk of F2 delivering a preterm baby (F3) if she was born preterm herself, and then to define the risk of F2 delivering preterm if her mother (F1) gave birth preterm during any of her birthing events. Results The risk for preterm delivery of the F2 parturient was 34% greater if their mother (F1) at any of her births had delivered preterm, controlling for parity, maternal age at delivery, and preeclampsia (adjusted odds ratio: 1.34, 95% confidence interval: -1.01 to 1.77; p = 0.042). Conclusion The family history of preterm delivery is an independent risk factor for preterm delivery. The family history includes the mother as well as one of the mother's sisters (F2 generation) being born preterm.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalAmerican Journal of Perinatology
Issue number4
StatePublished - 1 Mar 2017


  • delivery outcomes
  • family history
  • intergenerational factors
  • preterm delivery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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