TY - JOUR
T1 - Recurrence Rates Following Reconstruction Strategies After Wide Excision of Hidradenitis Suppurativa
T2 - A Systematic Review and Meta-analysis
AU - Ovadja, Zachri N.
AU - Zugaj, Mislav
AU - Jacobs, Wilco
AU - Van Der Horst, Chantal M.A.M.
AU - Lapid, Oren
N1 - Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - BACKGROUND Wide excision (WE) is generally considered to be the most common treatment for recurrent hidradenitis suppurativa. When performed, excision is followed by decisions regarding best options for management of the surgical defect. Different reconstructive strategies (RSs) have been used, with varying rates of recurrence.OBJECTIVE To provide an up-to-date systematic review of the complete literature for different RS after WE and their recurrence rates.METHODSA systematic literature search of the complete available literature and a meta-analysis of proportions were performed on the included studies.RESULTS Of a total of 1,813 retrieved articles, 79 were included in the analysis. Most were retrospective analyses, with only one randomized controlled trial (RCT) and 7 prospective analyses. The RS described were divided into primary closure (PC), secondary intention healing (SIH), skin graft (SG), and fasciocutaneous flaps (FCF). The average estimated recurrence for PC was 22.0% (95% confidence interval [CI], 8.0%-40.0%), for SIH 11.0% (95% CI, 5.0%-20.0%), for SG 2.0% (95% CI, 0.0%-5.0%), and for FCF 2.0% (95% CI, 1.0%-5.0%) (p <.001). Hidradenitis suppurativa below the umbilicus was significantly associated with overall recurrence (p =.006). Quality of evidence was poor, and the reporting of results was mostly heterogeneous.CONCLUSION After WE, PC has the highest recurrence rates, whereas SG and FCF have the lowest rates. There is a need for more RCTs and guidelines, to be able to report uniformly on treatment outcomes.
AB - BACKGROUND Wide excision (WE) is generally considered to be the most common treatment for recurrent hidradenitis suppurativa. When performed, excision is followed by decisions regarding best options for management of the surgical defect. Different reconstructive strategies (RSs) have been used, with varying rates of recurrence.OBJECTIVE To provide an up-to-date systematic review of the complete literature for different RS after WE and their recurrence rates.METHODSA systematic literature search of the complete available literature and a meta-analysis of proportions were performed on the included studies.RESULTS Of a total of 1,813 retrieved articles, 79 were included in the analysis. Most were retrospective analyses, with only one randomized controlled trial (RCT) and 7 prospective analyses. The RS described were divided into primary closure (PC), secondary intention healing (SIH), skin graft (SG), and fasciocutaneous flaps (FCF). The average estimated recurrence for PC was 22.0% (95% confidence interval [CI], 8.0%-40.0%), for SIH 11.0% (95% CI, 5.0%-20.0%), for SG 2.0% (95% CI, 0.0%-5.0%), and for FCF 2.0% (95% CI, 1.0%-5.0%) (p <.001). Hidradenitis suppurativa below the umbilicus was significantly associated with overall recurrence (p =.006). Quality of evidence was poor, and the reporting of results was mostly heterogeneous.CONCLUSION After WE, PC has the highest recurrence rates, whereas SG and FCF have the lowest rates. There is a need for more RCTs and guidelines, to be able to report uniformly on treatment outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85103808094&partnerID=8YFLogxK
U2 - 10.1097/DSS.0000000000002815
DO - 10.1097/DSS.0000000000002815
M3 - Review article
C2 - 33795566
AN - SCOPUS:85103808094
SN - 1076-0512
VL - 47
SP - E106-E110
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 4
ER -