Recurrent pregnancy loss and future risk of female malignancies

Ron Charach, Eyal Sheiner, Ofer Beharier, Ruslan Sergienko, Roy Kessous

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Purpose: To investigate whether patients with a history of recurrent pregnancy loss (RPL) have an increased risk for future female malignancies. Methods: A retrospective population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of RPL (2 or more consecutive pregnancy losses). Deliveries occurred between the years 1988 and 2013, with a mean follow-up duration of 12 years. Women with known malignancies before the index pregnancy were excluded from the analysis. Female malignancies were divided according to specific type including ovary, breast, uterine and uterine cervix. Kaplan–Meier survival curve was used to estimate the cumulative incidence of malignancies. Cox proportional hazards model was used to determine the adjusted hazard ratios (HR) for female malignancy after controlling for confounders. Results: During the study period, 106,265 patients met the inclusion criteria; 6.6% (n = 7052) of patients had a diagnosis of RPL. During the follow-up period, patients with RPL had a significantly increased risk of being diagnosed with female malignancies as a group, while individually there was an increased risk of breast and uterine cervix cancer. Using a Kaplan–Meier survival curve, patients with a history of RPL had a significantly higher cumulative incidence of female malignancies. Using a Cox proportional hazards model, adjusted for confounders such as smoking, parity, and diabetes mellitus, a history of RPL remained independently associated with female malignancies (adjusted HR 1.4; P = 0.003). Conclusions: RPL is independently associated with long-term female malignancies. Patients with a history of RPL may benefit from counseling and screening for breast and uterine cervix cancer in particular.

Original languageEnglish
Pages (from-to)781-787
Number of pages7
JournalArchives of Gynecology and Obstetrics
Issue number4
StatePublished - 1 Oct 2018
Externally publishedYes


  • Breast cancer
  • Cervical cancer
  • Long-term risk
  • Ovarian cancer
  • Recurrent pregnancy loss
  • Uterine cancer

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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