Red alga polysaccharides attenuate angiotensin II-induced inflammation in coronary endothelial cells

Rachel Hamias, Talya Wolak, Mahmoud Huleihel, Esther Paran, Oshrat Levy-Ontman

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The pro-inflammatory vasoconstrictor Angiotensin II can cause endothelial dysfunction and is considered to be one of the mediators of atherosclerosis. Our former results demonstrated that polysaccharides derived from the red alga Porphyridium sp. attenuate inflammatory processes by interfering with tumor necrosis factor-alpha-induced inflammation, in human coronary artery endothelial cells. However, the anti-inflammatory effect of these polysaccharides on inflammation processes occurring under Angiotensin II stimulation is yet unknown. Herein, we studied the polysaccharide's anti-inflammatory effect by quantification of inflammatory markers in Angiotensin II- stimulated Human Coronary Artery Endothelial Cells following pre-treatment with polysaccharides. Inflammatory atherosclerotic pathways up-regulated by Angiotensin II, including adhesion molecule expression and nuclear factor kappa-light-chain-enhancer of activated B cells translocation, were significantly attenuated or diminished in cells pre-treated with the polysaccharides. In addition, the polysaccharides increased the antioxidant response elements activity through the nuclear factor-E2-related factor 2- antioxidant protection system. These polysaccharide's promising abilities may be considered as a basis for future use as a therapeutic agent aimed at improving vascular health by attenuation of the inflammatory atherosclerotic process.

Original languageEnglish
Pages (from-to)944-951
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume500
Issue number4
DOIs
StatePublished - 12 Jun 2018

Keywords

  • Angiotensin II
  • Antioxidant
  • Antioxidant response element
  • Endothelial cells
  • Nuclear factor-E2-related factor 2
  • Polysaccharides

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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