Reduced graphene oxide-modified microelectrode for antipsychotic clozapine detection in finger-pricked blood

Rajendra P. Shukla, Remi Cazelles, Deanna L. Kelly, Hadar Ben-Yoav

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Clozapine (CLZ) is the most effective antipsychotic medication for schizophrenia and the only one whose efficacy can be predicted by a blood test. However, it is underutilized due to adverse side effects and burdensome treatment monitoring scheme. Here, we present the development of an electrochemical microsystem based on a microelectrode modified with reduced graphene oxide to enable minimally invasive, real-time and in situ monitoring of CLZ levels in a finger-pricked volume sample of undiluted serum. The outcome of this work will facilitate the development of miniaturized and wearable analytical devices, and will enable personalized schizophrenia treatment management.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages1324-1325
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 1 Jan 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • Clozapine
  • Microsystem
  • Reduced graphene oxide
  • Schizophrenia

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