Reduced PGE2 production induced by LPS after hyperthermia treatment by rat glial brain culture

D. Shemi; J. Kaplanski

doi:10.1016/S0306-4565(97)00069-7

Reduced PGE₂ production induced by LPS after hyperthermia treatment by rat glial brain culture

D. Shemi, J. Kaplanski

Basic Sciences Divisions

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Our purpose in this research was to investigate the effect of hyperthermia treatment (1 h incubation at 42°C) on the production of PGE₂ by rat glial cell cultures, under basal conditions following stimulation with lipopolysaccharide (LPS) and inhibition with indomethacin, nimesulide and dexamethasone. Stimulation of rat glial cells in cultures with LPS caused a significant elevation of PGE₂ production (7-12-fold). This stimulation was inhibited by indomethacin, nimesulide and dexamethasone. Hyperthermia treatment reduced markedly LPS stimulated PGE₂ production, but had only a mild effect on basal PGE₂ production.

Original language	English
Pages (from-to)	69-73
Number of pages	5
Journal	Journal of Thermal Biology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/S0306-4565(97)00069-7
State	Published - 1 Feb 1998

Keywords

Cultures
Dexa methasone
Glial cells
Hyperthermia
Indomethacin
Lipopolysaccharide
Nimesulide
Prostaglandins

ASJC Scopus subject areas

Biochemistry
Physiology
General Agricultural and Biological Sciences
Developmental Biology

Access to Document

10.1016/S0306-4565(97)00069-7

Cite this

@article{cf79765b076249bd8e074555c903845a,

title = "Reduced PGE2 production induced by LPS after hyperthermia treatment by rat glial brain culture",

abstract = "Our purpose in this research was to investigate the effect of hyperthermia treatment (1 h incubation at 42°C) on the production of PGE2 by rat glial cell cultures, under basal conditions following stimulation with lipopolysaccharide (LPS) and inhibition with indomethacin, nimesulide and dexamethasone. Stimulation of rat glial cells in cultures with LPS caused a significant elevation of PGE2 production (7-12-fold). This stimulation was inhibited by indomethacin, nimesulide and dexamethasone. Hyperthermia treatment reduced markedly LPS stimulated PGE2 production, but had only a mild effect on basal PGE2 production.",

keywords = "Cultures, Dexa methasone, Glial cells, Hyperthermia, Indomethacin, Lipopolysaccharide, Nimesulide, Prostaglandins",

author = "D. Shemi and J. Kaplanski",

year = "1998",

month = feb,

day = "1",

doi = "10.1016/S0306-4565(97)00069-7",

language = "English",

volume = "23",

pages = "69--73",

journal = "Journal of Thermal Biology",

issn = "0306-4565",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - Reduced PGE2 production induced by LPS after hyperthermia treatment by rat glial brain culture

AU - Shemi, D.

AU - Kaplanski, J.

PY - 1998/2/1

Y1 - 1998/2/1

N2 - Our purpose in this research was to investigate the effect of hyperthermia treatment (1 h incubation at 42°C) on the production of PGE2 by rat glial cell cultures, under basal conditions following stimulation with lipopolysaccharide (LPS) and inhibition with indomethacin, nimesulide and dexamethasone. Stimulation of rat glial cells in cultures with LPS caused a significant elevation of PGE2 production (7-12-fold). This stimulation was inhibited by indomethacin, nimesulide and dexamethasone. Hyperthermia treatment reduced markedly LPS stimulated PGE2 production, but had only a mild effect on basal PGE2 production.

AB - Our purpose in this research was to investigate the effect of hyperthermia treatment (1 h incubation at 42°C) on the production of PGE2 by rat glial cell cultures, under basal conditions following stimulation with lipopolysaccharide (LPS) and inhibition with indomethacin, nimesulide and dexamethasone. Stimulation of rat glial cells in cultures with LPS caused a significant elevation of PGE2 production (7-12-fold). This stimulation was inhibited by indomethacin, nimesulide and dexamethasone. Hyperthermia treatment reduced markedly LPS stimulated PGE2 production, but had only a mild effect on basal PGE2 production.

KW - Cultures

KW - Dexa methasone

KW - Glial cells

KW - Hyperthermia

KW - Indomethacin

KW - Lipopolysaccharide

KW - Nimesulide

KW - Prostaglandins

UR - http://www.scopus.com/inward/record.url?scp=0032003928&partnerID=8YFLogxK

U2 - 10.1016/S0306-4565(97)00069-7

DO - 10.1016/S0306-4565(97)00069-7

M3 - Article

AN - SCOPUS:0032003928

SN - 0306-4565

VL - 23

SP - 69

EP - 73

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

IS - 1

ER -