Our purpose in this research was to investigate the effect of hyperthermia treatment (1 h incubation at 42°C) on the production of PGE2 by rat glial cell cultures, under basal conditions following stimulation with lipopolysaccharide (LPS) and inhibition with indomethacin, nimesulide and dexamethasone. Stimulation of rat glial cells in cultures with LPS caused a significant elevation of PGE2 production (7-12-fold). This stimulation was inhibited by indomethacin, nimesulide and dexamethasone. Hyperthermia treatment reduced markedly LPS stimulated PGE2 production, but had only a mild effect on basal PGE2 production.
- Dexa methasone
- Glial cells
ASJC Scopus subject areas
- Agricultural and Biological Sciences (all)
- Developmental Biology