Reduced PGE2 production induced by LPS after hyperthermia treatment by rat glial brain culture

D. Shemi, J. Kaplanski

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1 Scopus citations

Abstract

Our purpose in this research was to investigate the effect of hyperthermia treatment (1 h incubation at 42°C) on the production of PGE2 by rat glial cell cultures, under basal conditions following stimulation with lipopolysaccharide (LPS) and inhibition with indomethacin, nimesulide and dexamethasone. Stimulation of rat glial cells in cultures with LPS caused a significant elevation of PGE2 production (7-12-fold). This stimulation was inhibited by indomethacin, nimesulide and dexamethasone. Hyperthermia treatment reduced markedly LPS stimulated PGE2 production, but had only a mild effect on basal PGE2 production.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of Thermal Biology
Volume23
Issue number1
DOIs
StatePublished - 1 Feb 1998

Keywords

  • Cultures
  • Dexa methasone
  • Glial cells
  • Hyperthermia
  • Indomethacin
  • Lipopolysaccharide
  • Nimesulide
  • Prostaglandins

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