Reduction of peritoneal adhesion formation by colchicine: A comparative study in the rat

M. Granat, I. Tur Kaspa, E. Zylber Katz, J. G. Schenker

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Colchicine inhibits processes known to be involved in the pathogenesis of peritoneal adhesions. Daily administration of 50 μg of colchicine to 22 rats significantly diminished adhesion formation, as compared with dexamethasone-treated and untreated rats. Rats that developed at least three adhesions of grade 3 (scale 0 to 4) were strikingly less prevalent among the colchicine-treated animals than the untreated group (9.1% versus 40.9%, P < 0.001). The double product of the number and grading of adhesions was significantly lower (P < 0.05) in the colchicine group. Colchicine is more effective than dexamethasone in inhibiting adhesion formation in the rat.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalFertility and Sterility
Volume40
Issue number3
DOIs
StatePublished - 1 Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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