Reduction of peritoneal adhesion formation by colchicine: A comparative study in the rat

M. Granat; I. Tur Kaspa; E. Zylber Katz; J. G. Schenker

doi:10.1016/S0015-0282(16)47302-4

Reduction of peritoneal adhesion formation by colchicine: A comparative study in the rat

M. Granat, I. Tur Kaspa, E. Zylber Katz, J. G. Schenker

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Abstract

Colchicine inhibits processes known to be involved in the pathogenesis of peritoneal adhesions. Daily administration of 50 μg of colchicine to 22 rats significantly diminished adhesion formation, as compared with dexamethasone-treated and untreated rats. Rats that developed at least three adhesions of grade 3 (scale 0 to 4) were strikingly less prevalent among the colchicine-treated animals than the untreated group (9.1% versus 40.9%, P < 0.001). The double product of the number and grading of adhesions was significantly lower (P < 0.05) in the colchicine group. Colchicine is more effective than dexamethasone in inhibiting adhesion formation in the rat.

Original language	English
Pages (from-to)	369-372
Number of pages	4
Journal	Fertility and Sterility
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/S0015-0282(16)47302-4
State	Published - 1 Jan 1983
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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abstract = "Colchicine inhibits processes known to be involved in the pathogenesis of peritoneal adhesions. Daily administration of 50 μg of colchicine to 22 rats significantly diminished adhesion formation, as compared with dexamethasone-treated and untreated rats. Rats that developed at least three adhesions of grade 3 (scale 0 to 4) were strikingly less prevalent among the colchicine-treated animals than the untreated group (9.1% versus 40.9%, P < 0.001). The double product of the number and grading of adhesions was significantly lower (P < 0.05) in the colchicine group. Colchicine is more effective than dexamethasone in inhibiting adhesion formation in the rat.",

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AU - Zylber Katz, E.

AU - Schenker, J. G.

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N2 - Colchicine inhibits processes known to be involved in the pathogenesis of peritoneal adhesions. Daily administration of 50 μg of colchicine to 22 rats significantly diminished adhesion formation, as compared with dexamethasone-treated and untreated rats. Rats that developed at least three adhesions of grade 3 (scale 0 to 4) were strikingly less prevalent among the colchicine-treated animals than the untreated group (9.1% versus 40.9%, P < 0.001). The double product of the number and grading of adhesions was significantly lower (P < 0.05) in the colchicine group. Colchicine is more effective than dexamethasone in inhibiting adhesion formation in the rat.

AB - Colchicine inhibits processes known to be involved in the pathogenesis of peritoneal adhesions. Daily administration of 50 μg of colchicine to 22 rats significantly diminished adhesion formation, as compared with dexamethasone-treated and untreated rats. Rats that developed at least three adhesions of grade 3 (scale 0 to 4) were strikingly less prevalent among the colchicine-treated animals than the untreated group (9.1% versus 40.9%, P < 0.001). The double product of the number and grading of adhesions was significantly lower (P < 0.05) in the colchicine group. Colchicine is more effective than dexamethasone in inhibiting adhesion formation in the rat.

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Reduction of peritoneal adhesion formation by colchicine: A comparative study in the rat

Abstract

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