Regioselective monoalkylation of dimethyl alkylidenesuccinates: Simple approach to dialkyl-substituted maleic anhydrides including chaetomellic acid A

Umesh A. Kshirsagar, Narshinha P. Argade

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Natural and nonnatural dialkylmaleic anhydrides were readily prepared from dimethyl alkylidenesuccinates by sodium hexamethyldisilazide-induced selective monoalkylation followed by base-catalyzed hydrolysis.

Original languageEnglish
Pages (from-to)1804-1808
Number of pages5
JournalSynthesis
Issue number11
DOIs
StatePublished - 27 May 2011
Externally publishedYes

Keywords

  • alkylations
  • esters
  • furans
  • heterocycles
  • maleic anhydrides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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