Regulated proteolysis in Gram-negative bacteria-how and when?

Eyal Gur, Dvora Biran, Eliora Z. Ron

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Most bacteria live in a dynamic environment where temperature, availability of nutrients and the presence of various chemicals vary, which requires rapid adaptation. Many of the adaptive changes are determined by changes in the transcription of global regulatory networks, but this response is slow because most bacterial proteins are stable and their concentration remains high even after transcription slows down. To respond rapidly, an additional level of regulation has evolved: the degradation of key proteins. However, as proteolysis is an irreversible process, it is subject to tight regulation of substrate binding and degradation. Here we review the roles of the proteolytic enzymes in Gram-negative bacteria and how these enzymes can be regulated to target only a subset of proteins.

Original languageEnglish
Pages (from-to)839-848
Number of pages10
JournalNature Reviews Microbiology
Issue number12
StatePublished - 1 Dec 2011

ASJC Scopus subject areas

  • Microbiology
  • General Immunology and Microbiology
  • Infectious Diseases


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