Regulation of cellular protein quality control networks in a multicellular organism

Yael Bar-Lavan, Libby Kosolapov, Anna Frumkin, Anat Ben-Zvi

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The long-term health of all metazoan cells is linked to protein quality control, which is achieved by proteostasis, a complex network of molecular interactions that determines the health of the proteome under physiological or stress conditions. Studying the regulation of cellular proteostasis in the context of the whole organism has unraveled multiple layers of cell-nonautonomous regulation, including neuronal regulation, cell-to-cell stress signals and endocrine signaling that affect growth, development and aging. Here, we discuss emerging concepts in cell-nonautonomous regulation of protein quality control networks. The identification of organismal modulators of cellular proteostasis may present novel, yet general targets for misfolding disease intervention.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalFEBS Journal
Issue number4
StatePublished - 1 Feb 2012


  • Caenorhabditis elegans
  • HSF1
  • aging
  • cell-nonautonomous regulation
  • heat shock response
  • mitochondrial-specific unfolded protein response
  • protein misfolding
  • protein misfolding diseases
  • proteostasis
  • stress responses


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