Regulation of glial cyclooxygenase by bradykinin

Einat Levy; Sigal Fleisher-Berkovich

doi:10.1016/j.peptides.2007.01.013

Regulation of glial cyclooxygenase by bradykinin

Einat Levy, Sigal Fleisher-Berkovich

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5 Scopus citations

Abstract

The aim of the present study was to investigate the short-term effect of bradykinin on the two cyclooxygenase species in neonatal rat glial cells. In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase activity was observed. Use of cyclooxygenase-1 inhibitors and paracetamol resulted in complete elimination of the bradykinin-induced prostaglandin E₂ synthesis and of cyclooxygenase enzyme activity. Cyclooxygenase-2 inhibitors only partially inhibited enzyme activity and prostaglandin production. Our data suggest that cyclooxygenase-1 is probably the major contributor to short-term modulation of glial prostaglandin E2 synthesis by bradykinin.

Original language	English
Pages (from-to)	845-850
Number of pages	6
Journal	Peptides
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.peptides.2007.01.013
State	Published - 1 Apr 2007

Keywords

Bradykinin
Cyclooxygenase
Glial cells
Prostaglandin E

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2007.01.013

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title = "Regulation of glial cyclooxygenase by bradykinin",

abstract = "The aim of the present study was to investigate the short-term effect of bradykinin on the two cyclooxygenase species in neonatal rat glial cells. In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase activity was observed. Use of cyclooxygenase-1 inhibitors and paracetamol resulted in complete elimination of the bradykinin-induced prostaglandin E2 synthesis and of cyclooxygenase enzyme activity. Cyclooxygenase-2 inhibitors only partially inhibited enzyme activity and prostaglandin production. Our data suggest that cyclooxygenase-1 is probably the major contributor to short-term modulation of glial prostaglandin E2 synthesis by bradykinin.",

keywords = "Bradykinin, Cyclooxygenase, Glial cells, Prostaglandin E",

author = "Einat Levy and Sigal Fleisher-Berkovich",

note = "Funding Information: We wish to thank Prof. Abraham Danon for his critical input to the studies plan and writing of the manuscript. “This research was supported by THE ISRAEL SCIENCE FOUNDATION (grant No. 500/04)”. ",

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T1 - Regulation of glial cyclooxygenase by bradykinin

AU - Levy, Einat

AU - Fleisher-Berkovich, Sigal

N1 - Funding Information: We wish to thank Prof. Abraham Danon for his critical input to the studies plan and writing of the manuscript. “This research was supported by THE ISRAEL SCIENCE FOUNDATION (grant No. 500/04)”.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - The aim of the present study was to investigate the short-term effect of bradykinin on the two cyclooxygenase species in neonatal rat glial cells. In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase activity was observed. Use of cyclooxygenase-1 inhibitors and paracetamol resulted in complete elimination of the bradykinin-induced prostaglandin E2 synthesis and of cyclooxygenase enzyme activity. Cyclooxygenase-2 inhibitors only partially inhibited enzyme activity and prostaglandin production. Our data suggest that cyclooxygenase-1 is probably the major contributor to short-term modulation of glial prostaglandin E2 synthesis by bradykinin.

AB - The aim of the present study was to investigate the short-term effect of bradykinin on the two cyclooxygenase species in neonatal rat glial cells. In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase activity was observed. Use of cyclooxygenase-1 inhibitors and paracetamol resulted in complete elimination of the bradykinin-induced prostaglandin E2 synthesis and of cyclooxygenase enzyme activity. Cyclooxygenase-2 inhibitors only partially inhibited enzyme activity and prostaglandin production. Our data suggest that cyclooxygenase-1 is probably the major contributor to short-term modulation of glial prostaglandin E2 synthesis by bradykinin.

KW - Bradykinin

KW - Cyclooxygenase

KW - Glial cells

KW - Prostaglandin E

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DO - 10.1016/j.peptides.2007.01.013

M3 - Article

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SN - 0196-9781

VL - 28

SP - 845

EP - 850

JO - Peptides

JF - Peptides

IS - 4

ER -

Regulation of glial cyclooxygenase by bradykinin

Abstract

Keywords

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