Regulation of glial cyclooxygenase by bradykinin

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    Abstract

    The aim of the present study was to investigate the short-term effect of bradykinin on the two cyclooxygenase species in neonatal rat glial cells. In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase activity was observed. Use of cyclooxygenase-1 inhibitors and paracetamol resulted in complete elimination of the bradykinin-induced prostaglandin E2 synthesis and of cyclooxygenase enzyme activity. Cyclooxygenase-2 inhibitors only partially inhibited enzyme activity and prostaglandin production. Our data suggest that cyclooxygenase-1 is probably the major contributor to short-term modulation of glial prostaglandin E2 synthesis by bradykinin.

    Original languageEnglish
    Pages (from-to)845-850
    Number of pages6
    JournalPeptides
    Volume28
    Issue number4
    DOIs
    StatePublished - 1 Apr 2007

    Keywords

    • Bradykinin
    • Cyclooxygenase
    • Glial cells
    • Prostaglandin E

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