Matrix metalloproteases (MMPs) are members of zinc-dependent enzymes involved in the degradation of extracellular matrix (ECM) components. Among these enzymes, membrane-type 1 MMP (MT1-MMP) has been established as a vital enzyme in pericellular proteolysis of the ECM macromolecules and shown to be involved in regulating different cellular and tissue characteristics and function in normal and pathological conditions. The enzyme is also important for skeletal development, cancer invasion, growth, neovessel formation, cell invasion as well as various signal transduction events. In this review, we summarize some information about regulation of MT1-MMP expression and activity and the recent knowledge of participation of MT1-MMP in different physiological and pathological events.
- Extracellular matrix
- Matrix metalloprotease
- Membrane type1 matrix metalloprotease
- Signal transduction
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology (all)