Regulation of MT1-MMP activation and its relevance to disease processes

Soumitra Roy; Tapati Chakraborti; Animesh Chowdhury; Kuntal Dey; Sajal Chakraborti

doi:10.1007/978-1-4614-9233-7_12

Regulation of MT1-MMP activation and its relevance to disease processes

Soumitra Roy, Tapati Chakraborti, Animesh Chowdhury, Kuntal Dey, Sajal Chakraborti

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Matrix metalloproteases (MMPs) are members of zinc-dependent enzymes involved in the degradation of extracellular matrix (ECM) components. Among these enzymes, membrane-type 1 MMP (MT1-MMP) has been established as a vital enzyme in pericellular proteolysis of the ECM macromolecules and shown to be involved in regulating different cellular and tissue characteristics and function in normal and pathological conditions. The enzyme is also important for skeletal development, cancer invasion, growth, neovessel formation, cell invasion as well as various signal transduction events. In this review, we summarize some information about regulation of MT1-MMP expression and activity and the recent knowledge of participation of MT1-MMP in different physiological and pathological events.

Original language	English
Title of host publication	Proteases in Health and Disease
Publisher	Springer New York
Pages	195-213
Number of pages	19
ISBN (Electronic)	9781461492337
ISBN (Print)	9781461492320
DOIs	https://doi.org/10.1007/978-1-4614-9233-7_12
State	Published - 1 Jan 2013
Externally published	Yes

Keywords

Angiogenesis
Extracellular matrix
Matrix metalloprotease
Membrane type1 matrix metalloprotease
Signal transduction

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4614-9233-7_12

Cite this

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abstract = "Matrix metalloproteases (MMPs) are members of zinc-dependent enzymes involved in the degradation of extracellular matrix (ECM) components. Among these enzymes, membrane-type 1 MMP (MT1-MMP) has been established as a vital enzyme in pericellular proteolysis of the ECM macromolecules and shown to be involved in regulating different cellular and tissue characteristics and function in normal and pathological conditions. The enzyme is also important for skeletal development, cancer invasion, growth, neovessel formation, cell invasion as well as various signal transduction events. In this review, we summarize some information about regulation of MT1-MMP expression and activity and the recent knowledge of participation of MT1-MMP in different physiological and pathological events.",

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AU - Chakraborti, Tapati

AU - Chowdhury, Animesh

AU - Dey, Kuntal

AU - Chakraborti, Sajal

N1 - Publisher Copyright: © Springer Science+Business Media New York 2013. All rights are reserved.

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KW - Extracellular matrix

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KW - Membrane type1 matrix metalloprotease

KW - Signal transduction

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BT - Proteases in Health and Disease

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Regulation of MT1-MMP activation and its relevance to disease processes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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