Regulation of MT1-MMP activation and its relevance to disease processes

Soumitra Roy, Tapati Chakraborti, Animesh Chowdhury, Kuntal Dey, Sajal Chakraborti

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Matrix metalloproteases (MMPs) are members of zinc-dependent enzymes involved in the degradation of extracellular matrix (ECM) components. Among these enzymes, membrane-type 1 MMP (MT1-MMP) has been established as a vital enzyme in pericellular proteolysis of the ECM macromolecules and shown to be involved in regulating different cellular and tissue characteristics and function in normal and pathological conditions. The enzyme is also important for skeletal development, cancer invasion, growth, neovessel formation, cell invasion as well as various signal transduction events. In this review, we summarize some information about regulation of MT1-MMP expression and activity and the recent knowledge of participation of MT1-MMP in different physiological and pathological events.

Original languageEnglish
Title of host publicationProteases in Health and Disease
PublisherSpringer New York
Number of pages19
ISBN (Electronic)9781461492337
ISBN (Print)9781461492320
StatePublished - 1 Jan 2013
Externally publishedYes


  • Angiogenesis
  • Extracellular matrix
  • Matrix metalloprotease
  • Membrane type1 matrix metalloprotease
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)


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