Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells

Yosef Graziani; Reuben Chayoth; Noga Karny; Bianka Feldman; Joseph Levy

doi:10.1016/0304-4165(82)90148-9

Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells

Yosef Graziani, Reuben Chayoth, Noga Karny, Bianka Feldman, Joseph Levy

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Cyclic AMP-independent protein kinase activities from Ehrlich ascites tumor cells, partially purified by DEAE-cellulose and phosphocellulose chromatography were inhibited by quercetin. The cyclic AMP in the tumor ascites cells and the cyclic AMP-dependent protein kinase activity from this tumor and from bovine and mouse tissues were unaffected by this drug. Since we reported that quercetin elevates cyclic AMP level in Ehrlich ascites tumor cells, this bioflavonoid may have a dual effect on the protein kinae activities in these cells, thus, increasing the cyclic AMP-dependent and decreasing the cyclic AMP-independent protein kinase activities.

Original language	English
Pages (from-to)	415-421
Number of pages	7
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	714
Issue number	3
DOIs	https://doi.org/10.1016/0304-4165(82)90148-9
State	Published - 25 Feb 1982

Keywords

(Ehrlich ascites cell)
Protein kinase inhibitor
Protein kinase regulation
Quercetin

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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10.1016/0304-4165(82)90148-9

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title = "Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells",

abstract = "Cyclic AMP-independent protein kinase activities from Ehrlich ascites tumor cells, partially purified by DEAE-cellulose and phosphocellulose chromatography were inhibited by quercetin. The cyclic AMP in the tumor ascites cells and the cyclic AMP-dependent protein kinase activity from this tumor and from bovine and mouse tissues were unaffected by this drug. Since we reported that quercetin elevates cyclic AMP level in Ehrlich ascites tumor cells, this bioflavonoid may have a dual effect on the protein kinae activities in these cells, thus, increasing the cyclic AMP-dependent and decreasing the cyclic AMP-independent protein kinase activities.",

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AU - Graziani, Yosef

AU - Chayoth, Reuben

AU - Karny, Noga

AU - Feldman, Bianka

AU - Levy, Joseph

PY - 1982/2/25

Y1 - 1982/2/25

N2 - Cyclic AMP-independent protein kinase activities from Ehrlich ascites tumor cells, partially purified by DEAE-cellulose and phosphocellulose chromatography were inhibited by quercetin. The cyclic AMP in the tumor ascites cells and the cyclic AMP-dependent protein kinase activity from this tumor and from bovine and mouse tissues were unaffected by this drug. Since we reported that quercetin elevates cyclic AMP level in Ehrlich ascites tumor cells, this bioflavonoid may have a dual effect on the protein kinae activities in these cells, thus, increasing the cyclic AMP-dependent and decreasing the cyclic AMP-independent protein kinase activities.

AB - Cyclic AMP-independent protein kinase activities from Ehrlich ascites tumor cells, partially purified by DEAE-cellulose and phosphocellulose chromatography were inhibited by quercetin. The cyclic AMP in the tumor ascites cells and the cyclic AMP-dependent protein kinase activity from this tumor and from bovine and mouse tissues were unaffected by this drug. Since we reported that quercetin elevates cyclic AMP level in Ehrlich ascites tumor cells, this bioflavonoid may have a dual effect on the protein kinae activities in these cells, thus, increasing the cyclic AMP-dependent and decreasing the cyclic AMP-independent protein kinase activities.

KW - (Ehrlich ascites cell)

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KW - Protein kinase regulation

KW - Quercetin

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Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells

Abstract

Keywords

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