Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells

Yosef Graziani, Reuben Chayoth, Noga Karny, Bianka Feldman, Joseph Levy

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Cyclic AMP-independent protein kinase activities from Ehrlich ascites tumor cells, partially purified by DEAE-cellulose and phosphocellulose chromatography were inhibited by quercetin. The cyclic AMP in the tumor ascites cells and the cyclic AMP-dependent protein kinase activity from this tumor and from bovine and mouse tissues were unaffected by this drug. Since we reported that quercetin elevates cyclic AMP level in Ehrlich ascites tumor cells, this bioflavonoid may have a dual effect on the protein kinae activities in these cells, thus, increasing the cyclic AMP-dependent and decreasing the cyclic AMP-independent protein kinase activities.

Original languageEnglish
Pages (from-to)415-421
Number of pages7
JournalBiochimica et Biophysica Acta - General Subjects
Volume714
Issue number3
DOIs
StatePublished - 25 Feb 1982

Keywords

  • (Ehrlich ascites cell)
  • Protein kinase inhibitor
  • Protein kinase regulation
  • Quercetin

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