Regulators of G-protein-coupled receptor-G-protein coupling: Antidepressants mechanism of action

Gabriel Schreiber, Sofia Avissar

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


There is a significant gap between advances in medication for mental disorders and the present static situation of biological diagnosis and monitoring treatment. The system of neural transmission and signal transduction is a complicated, highly regulated cascade of biochemical events. Growing evidence suggests that receptor-G-protein coupling may be involved in both the pathogenesis and treatment of mood disorders. Our knowledge concerning the basic mechanisms underlying the phenomenon of desensitization, internalization, downregulation and resensitization of the G-protein-coupled receptor has been advanced during the last decade. The present review discusses the possible involvement of regulators of G-protein-coupled receptor-G-protein coupling: β-arrestins, G-protein-coupled receptor kinases and phosducin-like proteins, as well as β-arrestins alternative signaling events, in the pathophysiology, diagnosis and treatment monitoring of mood disorders and in the mechanism of action of antidepressant medications.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalExpert Review of Neurotherapeutics
Issue number1
StatePublished - 1 Jan 2007


  • Antidepressant
  • B-arrestin
  • Diagnostic marker
  • G-protein-coupled receptor
  • G-protein-coupled receptor kinase
  • Mood disorder
  • Phosducin
  • Post-receptor signaling

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Pharmacology (medical)


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