Regulatory and innovative mechanisms of bacterial quorum sensing–mediated pathogenicity: a review

Sonam Tripathi, Diane Purchase, Muthusamy Govarthanan, Ram Chandra, Sangeeta Yadav

Research output: Contribution to journalArticlepeer-review


Quorum sensing (QS) is a system of bacteria in which cells communicate with each other; it is linked to cell density in the microbiome. The high-density colony population can provide enough small molecular signals to enable a range of cellular activities, gene expression, pathogenicity, and antibiotic resistance that cause damage to the hosts. QS is the basis of chronic illnesses in human due to microbial sporulation, expression of virulence factors, biofilm formation, secretion of enzymes, or production of membrane vesicles. The transfer of antimicrobial resistance gene (ARG) among antibiotic resistance bacteria is a major public health concern. QS-mediated biofilm is a hub for ARG horizontal gene transfer. To develop innovative approach to prevent microbial pathogenesis, it is essential to understand the role of QS especially in response to environmental stressors such as exposure to antibiotics. This review provides the latest knowledge on the relationship of QS and pathogenicity and explore the novel approach to control QS via quorum quenching (QQ) using QS inhibitors (QSIs) and QQ enzymes. The state-of-the art knowledge on the role of QS and the potential of using QQ will help to overcome the threats of rapidly emerging bacterial pathogenesis.

Original languageEnglish
Article number75
JournalEnvironmental Monitoring and Assessment
Issue number1
StatePublished - 1 Jan 2023
Externally publishedYes


  • Acylated homoserine lactone
  • Antibiotic sensitivity
  • Auto-inducers
  • Biofilm formation
  • Pathogenicity
  • Quorum quenching
  • Quorum sensing

ASJC Scopus subject areas

  • Environmental Science (all)
  • Pollution
  • Management, Monitoring, Policy and Law


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