Reinnervation of transplanted hypothalamic neurons by host aminergic fibers in rats

William F. Silverman, Paul F. Aravich, Timothy J. Collier, John A. Olschowka, John R. Sladek

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Fetal mediobasal hypothalamic tissue which receives an extensive noradrenergic innervation in the adult brain, was implanted into the vicinity of the medial forebrain bundle of adult rats to determine wether host noradrenergic fibers would innervate the eptopically placed tissue in an organotypic manner. Tissue from the site of implantation was prepared for light and ultrastructural immunocytochemistry at 6,12, or 20 weeks postsurgery. Putative host catecholamine fibers formed dense plexuses in localized portions of the grafts and made synaptic contacts with dendrites and somata of transplanted neurons. This suggests that a mature host central nervous system is capable of a region-specific integration of transplanted neurons.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalBrain Research
Issue number2
StatePublished - 2 Jun 1987
Externally publishedYes


  • Catecholamine
  • Immunocytochemistry
  • Neural transplant
  • Synapse
  • Ultrastructure

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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