@article{bffddcc2598044108b3fbc1d8a996ca3,
title = "Reinnervation of transplanted hypothalamic neurons by host aminergic fibers in rats",
abstract = "Fetal mediobasal hypothalamic tissue which receives an extensive noradrenergic innervation in the adult brain, was implanted into the vicinity of the medial forebrain bundle of adult rats to determine wether host noradrenergic fibers would innervate the eptopically placed tissue in an organotypic manner. Tissue from the site of implantation was prepared for light and ultrastructural immunocytochemistry at 6,12, or 20 weeks postsurgery. Putative host catecholamine fibers formed dense plexuses in localized portions of the grafts and made synaptic contacts with dendrites and somata of transplanted neurons. This suggests that a mature host central nervous system is capable of a region-specific integration of transplanted neurons.",
keywords = "Catecholamine, Immunocytochemistry, Neural transplant, Synapse, Ultrastructure",
author = "Silverman, {William F.} and Aravich, {Paul F.} and Collier, {Timothy J.} and Olschowka, {John A.} and Sladek, {John R.}",
note = "Funding Information: the transplants has now been undertaken. The authors would like to thank Ms. Sarah Kennedy and Ms. Barbara Blanchard for their technical 1 Arluison, M., Agid, Y., and Javoy, F., Dopaminergic nerve endings in the neostriatum of the rat. 2. Radioauto-graphic study following local microinjections of tritiated do-pamine, Neuroscience, 3 (1978) 657-683. 2 Beebe, B. K., Mollgard, K., Bj6rklund, A. and Stenevi, U., Ultrastructural evidence of synaptogenesis in the adult rat dentate gyrus from brain stem implants, Brain Re-search, 167 (1979) 391-395. 3 Bj6rklund, A. and Stenevi, U., Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons, Cell Tissue Res., 185 (1977) 289-302. 4 Bj6rklund, A. and Stenevi, U., Regeneration of mono-aminergic and cholinergic neurons in the mammalian cen-tral nervous system, Physiol. Rev., 59 (1979) 62-100. 5 Clarke, D.J., Gage, F.H. Nilsson, O.G. and Bj6rklund, A., Grafted septal neurons form cholinergic synaptic con-nections in the dentate gyrus of behaviorally impaired aged rats, J. Comp. Neurol., 252 (1986) 483-492. 6 Dunnett, S.B., Bj6rklund, A. Stenevi, U. and Iversen, S.D., Grafts of embryonic substantia nigra reinnervating the ventrolateral striatum ameliorate sensorimoter impair-ments and amnesia in rats with 6-OHDA lesions of the ni-grostriatal pathway, Brain Research, 229 (1981) 209-217. 7 Freund, T.F., Bolam, J.P., Bj6rklund, A., Stenevi, U., Dunnett, S.B., Powel J.F. and Smith, A.D., Efferent syn-aptic connections of grafted dopaminergic neurons reinner-vating the host neostriatum: a tyrosine hydroxylase immu-nocytochemical study, J. Neurosci., 5 (1985) 603-616. 8 Gash, D.M. and Sladek Jr., J.R., Vasopressin neurons grafted into Brattleboro rats: viability and activity, Pep-tides, 1 (1982) 11-14. 9 Hattori, T., FiNger, H.C., McGeer, P.L. and Maler, L., Analysis of the fine structure of dopaminergic nigrostriatal projection by electron microscopic autoradiography, Exp. Neurol., 41 (1973) 599-611. 10 Jaeger, C.B., Cytoarchitechtonics of substantia nigra grafts: a light and electron microscopic study of immuno-cytochemically identified dopaminergic neurons and fi-brous astrocytes, J. Comp. Neurol., 231 (1985) 121-135. 11 Kromer, L.F., Bj6rklund, A. and Stenevi, U., Innervation of embryonic hippocampal implants by regenerating axons of cholinergic septal neurons in the adult rat, Brain Re-search, 210 (1981) 153-159. 12 Kromer, L.F., Intracephalic embryonic transplants: a new experimental preparation for developmental neurobiology. In J.R. Sladek, Jr. and D.M. Gash (Eds.), Neural Trans-plants Development and Function, Plenum, New York, contributions to this work. This study was supported by AG T32 00107 (W.F.S.), NS 15816 (J.R.S.), and an ADRDA Faculty Scholar Award (T. J. C.).",
year = "1987",
month = jun,
day = "2",
doi = "10.1016/0006-8993(87)91146-2",
language = "English",
volume = "412",
pages = "375--380",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}