Relapse after electric barrier-induced voluntary abstinence: A review

Kenichiro Negishi, Ida Fredriksson, Jennifer M. Bossert, Abraham Zangen, Yavin Shaham

Research output: Contribution to journalReview articlepeer-review


Relapse to drug use during abstinence is a defining feature of addiction. To date, however, results from studies using rat relapse/reinstatement models have yet to result in FDA-approved medications for relapse prevention. To address this translational gap, we and others have developed rat models of relapse after voluntary abstinence from drug self-administration. One of these models is the electric barrier conflict model. Here, we introduce the model, and then review studies on behavioral and neuropharmacological mechanisms of cue-induced relapse and incubation of drug seeking (time-dependent increase in drug seeking during abstinence) after electric barrier-induced abstinence. We also briefly discuss future directions and potential clinical implications. One major conclusion of our review is that the brain mechanisms controlling drug relapse after electrical barrier-induced voluntary abstinence are likely distinct from those controlling relapse after homecage forced abstinence.

Original languageEnglish
Article number102856
JournalCurrent Opinion in Neurobiology
StatePublished - 1 Jun 2024

ASJC Scopus subject areas

  • General Neuroscience


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