Relapse of cutaneous leishmaniasis in a patient with an infected subcutaneous rheumatoid nodule

Daniel A. Vardy, A. Cohen, L. Kachko, A. Zvulunov, S. Frankenburg

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations

    Abstract

    Cutaneous leishmaniasis is a protozoal infection generally considered to be limited to the skin. In Israel, the disease is common in geographically defined areas and is caused predominantly by Leishmania major. Sporotrichoid subcutaneous spread has been reported but is uncommon. We describe a patient with rheumatoid arthritis, treated with methotrexate and prednisone, in whom numerous rheumatoid nodules concomitant with cutaneous leishmaniasis were found, mimicking sporotrichoid spread of the disease. In a rheumatoid nodule that was examined by electron microscopy, Leishmania parasites were found at intracellular and extracellular locations. This observation supports the hypothesis that cutaneous leishmaniasis parasites persist after clinical cure of the disease and may re-emerge as a result of immunosuppression.

    Original languageEnglish
    Pages (from-to)914-917
    Number of pages4
    JournalBritish Journal of Dermatology
    Volume141
    Issue number5
    DOIs
    StatePublished - 13 Dec 1999

    Keywords

    • Cutaneous leishmaniasis
    • Rheumatoid nodule
    • Subcutaneous

    Fingerprint

    Dive into the research topics of 'Relapse of cutaneous leishmaniasis in a patient with an infected subcutaneous rheumatoid nodule'. Together they form a unique fingerprint.

    Cite this