Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes

Edith Grene; Guna Mezule; Galina Borisova; Paul Pumpens; Zvi Bentwich; Ruth Arnon

doi:10.1089/aid.1997.13.41

Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes

Edith Grene, Guna Mezule, Galina Borisova, Paul Pumpens, Zvi Bentwich, Ruth Arnon

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121- 210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160- 192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.

Original language	English
Pages (from-to)	41-51
Number of pages	11
Journal	AIDS Research and Human Retroviruses
Volume	13
Issue number	1
DOIs	https://doi.org/10.1089/aid.1997.13.41
State	Published - 1 Jan 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1089/aid.1997.13.41

Cite this

@article{66c72d8a84634b588c12f1bb637eccc8,

title = "Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes",

abstract = "We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121- 210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160- 192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.",

author = "Edith Grene and Guna Mezule and Galina Borisova and Paul Pumpens and Zvi Bentwich and Ruth Arnon",

year = "1997",

month = jan,

day = "1",

doi = "10.1089/aid.1997.13.41",

language = "English",

volume = "13",

pages = "41--51",

journal = "AIDS Research and Human Retroviruses",

issn = "0889-2229",

publisher = "Mary Ann Liebert Inc.",

number = "1",

}

TY - JOUR

T1 - Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes

AU - Grene, Edith

AU - Mezule, Guna

AU - Borisova, Galina

AU - Pumpens, Paul

AU - Bentwich, Zvi

AU - Arnon, Ruth

PY - 1997/1/1

Y1 - 1997/1/1

N2 - We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121- 210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160- 192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.

AB - We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121- 210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160- 192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.

UR - http://www.scopus.com/inward/record.url?scp=0031011936&partnerID=8YFLogxK

U2 - 10.1089/aid.1997.13.41

DO - 10.1089/aid.1997.13.41

M3 - Article

C2 - 8989426

AN - SCOPUS:0031011936

SN - 0889-2229

VL - 13

SP - 41

EP - 51

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

IS - 1

ER -

Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this