Relationships between platelet and plasma monoamine oxidase, plasma dopamine-B-hydroxylase, and urinary 3-methoxy-4-hydroxy phenylglycol

Robert Belmaker; Helmut Beckmann; Frederick Goodwin; Dennis Murphy; William Pollin; Monte Buchsbaum; Richard Wyatt; Roland Ciaranello; Friedhelm Lamprecht

doi:10.1016/0024-3205(75)90025-9

Relationships between platelet and plasma monoamine oxidase, plasma dopamine-B-hydroxylase, and urinary 3-methoxy-4-hydroxy phenylglycol

Robert Belmaker, Helmut Beckmann, Frederick Goodwin, Dennis Murphy, William Pollin, Monte Buchsbaum, Richard Wyatt, Roland Ciaranello, Friedhelm Lamprecht

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The activity of dopamine-B-hydroxylase in blood has recently been demonstrated to be under genetic control and to correlate closely with urinary catecholamine excretion. The results of the present study did not demonstrate any relationship between a major catecholamine metabolite in urine, 3-methoxy-4-hydroxy phenylglycol, and dopamine-B-hydroxylase activity in plasma, monoamine oxidase activity in platelets, or monoamine oxidase activity in plasma. Differences in the origin of urinary catecholamines and urinary 3-methoxy-4-hydroxy phenyglycol may be responsible for these divergent results.

Original language	English
Pages (from-to)	273-279
Number of pages	7
Journal	Life Sciences
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(75)90025-9
State	Published - 15 Jan 1975
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/0024-3205(75)90025-9

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title = "Relationships between platelet and plasma monoamine oxidase, plasma dopamine-B-hydroxylase, and urinary 3-methoxy-4-hydroxy phenylglycol",

abstract = "The activity of dopamine-B-hydroxylase in blood has recently been demonstrated to be under genetic control and to correlate closely with urinary catecholamine excretion. The results of the present study did not demonstrate any relationship between a major catecholamine metabolite in urine, 3-methoxy-4-hydroxy phenylglycol, and dopamine-B-hydroxylase activity in plasma, monoamine oxidase activity in platelets, or monoamine oxidase activity in plasma. Differences in the origin of urinary catecholamines and urinary 3-methoxy-4-hydroxy phenyglycol may be responsible for these divergent results.",

author = "Robert Belmaker and Helmut Beckmann and Frederick Goodwin and Dennis Murphy and William Pollin and Monte Buchsbaum and Richard Wyatt and Roland Ciaranello and Friedhelm Lamprecht",

year = "1975",

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doi = "10.1016/0024-3205(75)90025-9",

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journal = "Life Sciences",

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TY - JOUR

T1 - Relationships between platelet and plasma monoamine oxidase, plasma dopamine-B-hydroxylase, and urinary 3-methoxy-4-hydroxy phenylglycol

AU - Belmaker, Robert

AU - Beckmann, Helmut

AU - Goodwin, Frederick

AU - Murphy, Dennis

AU - Pollin, William

AU - Buchsbaum, Monte

AU - Wyatt, Richard

AU - Ciaranello, Roland

AU - Lamprecht, Friedhelm

PY - 1975/1/15

Y1 - 1975/1/15

N2 - The activity of dopamine-B-hydroxylase in blood has recently been demonstrated to be under genetic control and to correlate closely with urinary catecholamine excretion. The results of the present study did not demonstrate any relationship between a major catecholamine metabolite in urine, 3-methoxy-4-hydroxy phenylglycol, and dopamine-B-hydroxylase activity in plasma, monoamine oxidase activity in platelets, or monoamine oxidase activity in plasma. Differences in the origin of urinary catecholamines and urinary 3-methoxy-4-hydroxy phenyglycol may be responsible for these divergent results.

AB - The activity of dopamine-B-hydroxylase in blood has recently been demonstrated to be under genetic control and to correlate closely with urinary catecholamine excretion. The results of the present study did not demonstrate any relationship between a major catecholamine metabolite in urine, 3-methoxy-4-hydroxy phenylglycol, and dopamine-B-hydroxylase activity in plasma, monoamine oxidase activity in platelets, or monoamine oxidase activity in plasma. Differences in the origin of urinary catecholamines and urinary 3-methoxy-4-hydroxy phenyglycol may be responsible for these divergent results.

UR - http://www.scopus.com/inward/record.url?scp=0016441263&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(75)90025-9

DO - 10.1016/0024-3205(75)90025-9

M3 - Article

AN - SCOPUS:0016441263

SN - 0024-3205

VL - 16

SP - 273

EP - 279

JO - Life Sciences

JF - Life Sciences

IS - 2

ER -

Relationships between platelet and plasma monoamine oxidase, plasma dopamine-B-hydroxylase, and urinary 3-methoxy-4-hydroxy phenylglycol

Abstract

ASJC Scopus subject areas

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