Relative toxicities of major particulate matter constituents on birthweight in Massachusetts

Kelvin C. Fong, Qian Di, Itai Kloog, Francine Laden, Brent A. Coull, Petros Koutrakis, Joel D. Schwartz

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Maternal exposure to fine particulate air pollution (PM2.5) during pregnancy has been linked to lower newborn birthweight, making it a toxic exposure because lower birthweight is a risk factor for chronic disease and mortality. However, the toxicity of major constituents of PM2.5 and how they compare to each other remain uncertain. Methods: We assigned address-specific exposure to PM2.5, elemental carbon (EC), organic carbon (OC), nitrate, and sulfate averaged over the entire period of pregnancy for each birth in Massachusetts from 2001 to 2012 using a high-resolution exposure model. Using multivariate regression adjusted for total PM2.5, we estimated the relative toxicity of each constituent on continuous birthweight. Results: EC was more toxic per interquartile range increase compared with remaining PM2.5 in single constituent models that estimated the effect of a constituent with adjustment for PM2.5. OC, nitrate, and sulfate were each less toxic than their respective remaining PM2.5 per interquartile range increase. When all constituents and total PM2.5 were included in the same model, EC was most toxic, followed by nitrate, then OC and sulfate with similar toxicities. Sensitivity analyses using term low birth weight and small for gestational age also showed that EC was most detrimental as did averaging exposures over the third trimester of pregnancy. Scaling to unit mass increases also showed EC to be most toxic. Conclusion: Four major constituents of PM2.5 had different relative toxicities on continuous birthweight. Our findings suggest that EC was most toxic, followed by nitrate, OC, and sulfate.

Original languageEnglish
Article numbere047
JournalEnvironmental epidemiology (Philadelphia, Pa.)
Issue number3
StatePublished - May 2019

ASJC Scopus subject areas

  • Epidemiology
  • Global and Planetary Change
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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