Release of clotting factors from photosensitized endothelial cells: A possible trigger for blood vessel occlusion by photodynamic therapy

E. Ben-Hur, E. Heldman, S. W. Crane, I. Rosenthal

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Photodynamic treatment of solid tumors results in the occlusion of blood vessels in the treated tissue. We hypothesize that this process is triggered by the release of one or more clotting factors from the photodamaged endothelial cells. Experimental evidence is presented that immediately after photodynamic treatment, cultured endothelial cells start releasing clotting factors into the medium in a dose range of minimal cytotoxicity.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalFEBS Letters
Volume236
Issue number1
DOIs
StatePublished - 15 Aug 1988
Externally publishedYes

Keywords

  • Photodynamic therapy
  • Photosensitization
  • Phthalocyanine: Clotting factor: Endothelial cell

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint

Dive into the research topics of 'Release of clotting factors from photosensitized endothelial cells: A possible trigger for blood vessel occlusion by photodynamic therapy'. Together they form a unique fingerprint.

Cite this