Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks

Alexander Dvilansky, Shmuel Rishpon, Ilana Nathan, Zippora Zolotow, Amos D. Korczyn

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with 14 C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor (s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalPain
Volume2
Issue number3
DOIs
StatePublished - 1 Jan 1976
Externally publishedYes

Fingerprint

Dive into the research topics of 'Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks'. Together they form a unique fingerprint.

Cite this