Remodeling of proteostasis upon transition to adulthood is linked to reproduction onset

Nadav Shai, Netta Shemesh, Anat Ben-Zvi

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widespread failure early in Caenorhabditis elegans adulthood, with marked consequences on proteostasis functions later in life. These changes in the regulation of quality control systems, such as chaperones, the ubiquitin proteasome system and cellular stress responses, are controlled cell-nonautonomously by the proliferation of germline stem cells. Here, we review recent studies examining changes in proteostasis upon transition to adulthood and how proteostasis is modulated by reproduction onset, focusing on C. elegans. Based on these and our own findings, we propose that the regulation of quality control systems is actively remodeled at the point of transition between development and adulthood to influence the subsequent course of aging.

Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalCurrent Genomics
Volume15
Issue number2
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Aging
  • Autophagy
  • Caenorhabditis elegans
  • Chaperones
  • Folding
  • Germline stem cells
  • Misfolding
  • Ubiquitin proteasome system

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