Renal clearance of digoxin in young infants

R. Gorodischer, W. J. Jusko, S. J. Yaffe

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The renal clearance of digoxin and creatinine were measured in eleven infants, aged one to five months, with congenital heart disease and heart failure. The renal clearances of digoxin were low at one month of age (50 ml/min/1.73 m2) but increased progressively until the adult range was attained at about five months of age (130-150 ml/min/1.73 m2). At any given age, however, the renal clearance of digoxin was almost twice as great as the simultaneously determined creatinine clearance (mean ratio 1.73). This stands in marked contrast to older subjects where creatinine and digoxin clearances are usually similar. These data explain (in part) the larger digoxin dosage requirement of infants.

Original languageEnglish
Pages (from-to)363-374
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume16
Issue number2
StatePublished - 1 Jan 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics (all)

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