TY - JOUR
T1 - Renal handling of sodium, water and divalent ions in patients with primary biliary cirrhosis.
AU - Rochman, J.
AU - Chaimovitz, C.
AU - Eidelman, S.
AU - Better, O. S.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - 1) Fluid retention and ascites are rarely seen in patients with primary biliary cirrhosis (PBC). In an attempt to clarify this clinical observation, renal handling of sodium, water and divalent ions was studied during extracellular volume expansion (ECVE) and maximal suppression of antidiuretic hormone (ADH) secretion in 5 patients with PBC and 9 normal subjects. 2) Mean fractional excretion of sodium, water, phosphate and calculated fractional distal delivery of sodium were significantly greater in patients with PBC as compared with normal controls. Fractional CH20 for given fractional urine flow was similar in patients with PBC and normals. 3) The data suggest that patients with PBC have a greater diminution of proximal tubular reabsorption of sodium in response to ECVE than controls. This augmented elimination of salt during ECVE in patients with PBC may explain the rarity of ascites and edema in this type of cirrhosis.
AB - 1) Fluid retention and ascites are rarely seen in patients with primary biliary cirrhosis (PBC). In an attempt to clarify this clinical observation, renal handling of sodium, water and divalent ions was studied during extracellular volume expansion (ECVE) and maximal suppression of antidiuretic hormone (ADH) secretion in 5 patients with PBC and 9 normal subjects. 2) Mean fractional excretion of sodium, water, phosphate and calculated fractional distal delivery of sodium were significantly greater in patients with PBC as compared with normal controls. Fractional CH20 for given fractional urine flow was similar in patients with PBC and normals. 3) The data suggest that patients with PBC have a greater diminution of proximal tubular reabsorption of sodium in response to ECVE than controls. This augmented elimination of salt during ECVE in patients with PBC may explain the rarity of ascites and edema in this type of cirrhosis.
UR - http://www.scopus.com/inward/record.url?scp=0017341556&partnerID=8YFLogxK
U2 - 10.1007/978-1-4613-4217-5_14
DO - 10.1007/978-1-4613-4217-5_14
M3 - Article
C2 - 899921
AN - SCOPUS:0017341556
SN - 0065-2598
VL - 81
SP - 121
EP - 129
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -