Renal response to acute ammonium chloride acidosis in subjects with single kidney

J. C.M. Chan, R. S. Ma, M. H. Malekzadeh, J. K. Hurley, C. Chaimovitz

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations


    The renal response to acute ammonium chloride ingestion (75 mEq per m2) is quantitated in 3 normal adults and 5 normal kidney donors (mean of 400 days after unilateral nephrectomy). The adequate renal tubular response to metabolic acidoses in the normal subjects is evident with nearly complete correction of the systemic acidosis at 1,920 min after ammonium chloride ingestion. This is sharply contrasted in the persistence of acidosis in the single kidney subjects. The net acid excretion is consistently lower in the single kidney subjects as compared to the normal subjects. The etiology of this acidification defect is best explained by invoking the role of the reduced renal mass despite a 20% compensatory increase in GFR. It is anticipated that this study will provide control data for the studies of kidney allograft recipients with abnormal renal function.

    Original languageEnglish
    Pages (from-to)315-320
    Number of pages6
    JournalJournal of Urology
    Issue number3
    StatePublished - 1 Jan 1974

    ASJC Scopus subject areas

    • Urology


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