Renovation of the injured heart with myocardial tissue engineering

Jonathan Leor, Natali Landa, Smadar Cohen

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Tissue engineering aims to create, repair and/or replace tissues and organs by using cells, scaffolds, biologically active molecules and physiologic signals. It is an interdisciplinary field that integrates aspects of engineering, chemistry, biology and medicine. One of the most challenging goals in the field of cardiovascular tissue engineering is the creation of a heart muscle patch. This review describes the principles, achievements and challenges of achieving this ambitious goal of creating contractile heart muscle. In addition, the new strategy of in situ and injectable tissue engineering for myocardial repair and regeneration is presented.

Original languageEnglish
Pages (from-to)239-252
Number of pages14
JournalExpert Review of Cardiovascular Therapy
Volume4
Issue number2
DOIs
StatePublished - 1 Mar 2006

Keywords

  • Biomaterials
  • Cell
  • Heart
  • Matrix
  • Regeneration
  • Tissue engineering

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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