Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers

Keyphrases

• Leucine-rich Repeat Kinase 2 (LRRK2) 100%
• Putamen 100%
• Corticostriatal Circuits 100%
• Mutation Carriers 80%
• LRRK2 G2019S mutation 80%
• Parkinson's Disease 60%
• Pre-motor Parkinson's Disease 60%
• Functional Connectivity 40%
• Corticostriatal Circuitry 40%
• Functional Magnetic Resonance Imaging 20%
• System Level 20%
• Healthy Carriers 20%
• Human Model 20%
• Circuit Level 20%
• Severely Affected 20%
• Non-carriers 20%
• Increasing Age 20%
• Premotor 20%
• Basal Ganglia 20%
• LRRK2 mutation 20%
• Dopamine Depletion 20%
• Idiopathic Parkinson's Disease 20%
• Striatal Dopamine 20%
• Compensatory Changes 20%
• Corticostriatal 20%
• Inferior Parietal Cortex 20%
• Striatal Subregions 20%
• Age-related Risk 20%
• Parallel Topology 20%
• Thalamocortical Loop 20%

Neuroscience

• Parkinson's Disease 100%
• Putamen 71%
• Functional Connectivity 28%
• Functional Magnetic Resonance Imaging 14%
• Basal Ganglia 14%
• Parietal Cortex 14%