Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: An open-label study

Yuval Bloch, Nimrod Grisaru, Eiran V. Harel, Gabriela Beitler, Nurit Faivel, Gideon Ratzoni, Daniel Stein, Yechiel Levkovitz

    Research output: Contribution to journalArticlepeer-review

    69 Scopus citations

    Abstract

    Objective: This open-label pilot study examined repetitive transcranial magnetic stimulation as a possible treatment of adolescent resistant depression. Method: Nine adolescents (aged 16-18 years) with severe resistant depression (determined by SCID) were recruited, and their depression, suicidality, and cognitive functions were evaluated before, during, and after a course of twenty 10-Hz, 2-second trains (intertrain intervals of 58 seconds) given over 20 min/d over 14 working days. Results: Lower levels of depression with progression in therapy were recorded by both the Beck Depression Inventory and Child Depression Rating Scale measures (F1.7,14.01 ≤ 4.52, P < 0.05; F4,32 ≤ 6.645, P < 0.01, respectively). Three patients reached the primary outcome measure of less than 30% reduction in their Child Depression Rating Scale. The effect on suicidality was not significant. Side effects were considered mild. Conclusions: Repetitive transcranial magnetic stimulation might be a possible therapy for adolescent depression. Our preliminary findings warrant double-blind, controlled studies.

    Original languageEnglish
    Pages (from-to)156-159
    Number of pages4
    JournalJournal of ECT
    Volume24
    Issue number2
    DOIs
    StatePublished - 1 Jun 2008

    Keywords

    • Adolescents
    • Depression
    • Transcranial magnetic stimulation

    ASJC Scopus subject areas

    • Neuroscience (miscellaneous)
    • Psychiatry and Mental health

    Fingerprint

    Dive into the research topics of 'Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: An open-label study'. Together they form a unique fingerprint.

    Cite this