Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in Posttraumatic Stress Disorder: A Double-Blind, Placebo-Controlled Study

Hagit Cohen, Zeev Kaplan, Moshe Kotler, Irena Kouperman, Regina Moisa, Nimrod Grisaru

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

Objective: The efficacy of repetitive transcranial magnetic stimulation (rTMS) of the right prefrontal cortex was studied in patients with posttraumatic stress disorder (PTSD) under double-blind, placebo-controlled conditions. Method: Twenty-four patients with PTSD were randomly assigned to receive rTMS at low frequency (1 Hz) or high frequency (10 Hz) or sham rTMS in a double-blind design. Treatment was administered in 10 daily sessions over 2 weeks. Severity of PTSD, depression, and anxiety were blindly assessed before, during, and after completion of the treatment protocol. Results: The 10 daily treatments of 10Hz rTMS at 80% motor threshold over the right dorsolateral prefrontal cortex had therapeutic effects on PTSD patients. PTSD core symptoms (reexperiencing, avoidance) markedly improved with this treatment. Moreover, high-frequency rTMS over the right dorsolateral prefrontal cortex alleviated anxiety symptoms in PTSD patients. Conclusions: This double-blind, controlled trial suggests that in PTSD patients, 10 daily sessions of right dorsolateral prefrontal rTMS at a frequency of 10 Hz have greater therapeutic effects than slow-frequency or sham stimulation.

Original languageEnglish
Pages (from-to)515-524
Number of pages10
JournalAmerican Journal of Psychiatry
Volume161
Issue number3
DOIs
StatePublished - 1 Mar 2004

ASJC Scopus subject areas

  • Psychiatry and Mental health

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