Replication or inactivation of different viruses by human lymphocyte preparations

A. M. Denman, B. Rager Zisman, T. C. Merigan, D. A.J. Tyrrell

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Cultures of phytohemagglutinin stimulated, unstimulated, and frozen and thawed mononuclear (as controls) cells from normal human donors were infected with different viruses. A variable pattern of virus infectivity was noted, and influenza and Coxsackie virus were rapidly inactivated even by stimulated lymphocytes. Direct inactivation by lymphocytes may be one form of host defense in infection by some viruses.

Original languageEnglish
Pages (from-to)373-376
Number of pages4
JournalInfection and Immunity
Issue number2
StatePublished - 1 Jan 1974
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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