Replication time of the chromosome in thymineless mutants of Escherichia coli

A. Zaritsky, E. H. Pritchard

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Reducing the concentration of thymine in the growth medium of thy- mutants of Escherichia coli progressively increases the replication time of their chromosomes, without affecting significantly the growth rate of the cultures, down to a concentration that is strain-specific. The replication time of the chromosome of thy- mutants of two unrelated strains of E. coli was estimated to be longer than that in E. coli B r thy+ even in the presence of saturating concentrations of thymine. The replication time could be further reduced by adding deoxyguanosine as well as thymine to the growth medium.

Original languageEnglish
Pages (from-to)65-74
Number of pages10
JournalJournal of Molecular Biology
Issue number1
StatePublished - 28 Aug 1971
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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