Reprogramming cells for transplantation

Jonathan Leor; Alexander Battler; Robert A. Kloner; Sharon Etzion

doi:10.1023/A:1024786020652

Reprogramming cells for transplantation

Jonathan Leor, Alexander Battler, Robert A. Kloner, Sharon Etzion

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The field of tissue engineering, involving the reprogramming of stem cells or rejuvenation of specific differentiated cells, is emerging as a promising strategy to repair the damaged myocardium. The eventual goal is to be able to take a patient's own cells, expand them ex vivo, genetically engineer them to enhance specific properties, and then reintroduce them into the patient's heart to create a replacement tissue. Our review paper describes data that supports the potential of this strategy. This clinically relevant, combined strategy of genetic and tissue engineering could be of importance in treating elderly patients with massive myocardial damage, patients whose normal myogenic or angiogenic cells have been depleted or are inadequate in their growth potential, to prevent LV deterioration and heart failure.

Original language	English
Pages (from-to)	285-292
Number of pages	8
Journal	Heart Failure Reviews
Volume	8
Issue number	3
DOIs	https://doi.org/10.1023/A:1024786020652
State	Published - 1 Jul 2003
Externally published	Yes

Keywords

Cell transplantation
Cloning
Gene
Gene therapy,
MyoD
Telomerase
Tissue engineering

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1024786020652

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title = "Reprogramming cells for transplantation",

abstract = "The field of tissue engineering, involving the reprogramming of stem cells or rejuvenation of specific differentiated cells, is emerging as a promising strategy to repair the damaged myocardium. The eventual goal is to be able to take a patient's own cells, expand them ex vivo, genetically engineer them to enhance specific properties, and then reintroduce them into the patient's heart to create a replacement tissue. Our review paper describes data that supports the potential of this strategy. This clinically relevant, combined strategy of genetic and tissue engineering could be of importance in treating elderly patients with massive myocardial damage, patients whose normal myogenic or angiogenic cells have been depleted or are inadequate in their growth potential, to prevent LV deterioration and heart failure.",

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AU - Battler, Alexander

AU - Kloner, Robert A.

AU - Etzion, Sharon

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AB - The field of tissue engineering, involving the reprogramming of stem cells or rejuvenation of specific differentiated cells, is emerging as a promising strategy to repair the damaged myocardium. The eventual goal is to be able to take a patient's own cells, expand them ex vivo, genetically engineer them to enhance specific properties, and then reintroduce them into the patient's heart to create a replacement tissue. Our review paper describes data that supports the potential of this strategy. This clinically relevant, combined strategy of genetic and tissue engineering could be of importance in treating elderly patients with massive myocardial damage, patients whose normal myogenic or angiogenic cells have been depleted or are inadequate in their growth potential, to prevent LV deterioration and heart failure.

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KW - Cloning

KW - Gene

KW - Gene therapy,

KW - MyoD

KW - Telomerase

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Reprogramming cells for transplantation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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