Research developments in immunomodulatory and antioxidant activities of shilajatu

Rohit Singh, Shreshtha Kaushik, Pramod Yadav, Galib Ruknuddin, Pradeep K. Prajapati

Research output: Contribution to journalReview articlepeer-review


Ayurveda focuses upon preventing and promoting health along with curing of diseases in a systematic way. Ayurvedic literature has numerous single and compound plant-based, herbo-mineral, herbo-metallic formulations for general well being and in disease-specifi c conditions relating to geriatrics. Rasayana is a specialized branch that deals with the problems related to ageing and methods to counter the same. Shilajatu is one such compound, which has been used in Ayurveda for centuries as Rasayana and as a treatment for all the ailments of body. It is composed of mainly humic acid (60-80 %), and fulvic acid, oxygenated dibenzo- -pyrones and minerals in ionic form (20-40 %). This article is aimed at analyzing and disseminating the classical concepts and available published researches inferring antioxidant and immunomodulatory properties of Shilajatu. The review reveals that Shilajatu exhibits signifi cant antioxidant, immunomodulatory, chelating, cognitive and memory enhancing activities, thus it could prove to be a panacea for mankind.

Original languageEnglish
Pages (from-to)7-20
Number of pages14
JournalIndian Drugs
Issue number9
StatePublished - 1 Sep 2021
Externally publishedYes


  • Antioxidant
  • Fulvic acid
  • Humic acid
  • Immunomodulatory
  • Rasayana
  • Shilajatu

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery


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