Resistances and compliances of a compartmental model of the cerebrovascular system

Shaul Sorek, Jacob Bear, Zvi Karni

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A lumped parameter compartmental model for the nonsteady flow of the cerebrovascular fluid is constructed. The model assumes constant resistances that relate fluid flux to pressure gradients, and compliances between compartments that relate fluid accumulation to rate of pressure changes. Resistances are evaluated by using mean values of artery and cerebrospinal fluid (CSF) fluxes and mean compartmental pressures. Compliances are then evaluated from clinical data of simultaneous pulse wave recordings in the different compartments. Estimate of the average CSF compartmental deformation, based on the compliance between the CSF and brain tissue compartments, proves to be of the order of magnitude of actual experimental measurements.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalAnnals of Biomedical Engineering
Volume17
Issue number1
DOIs
StatePublished - 1 Jan 1989

Keywords

  • Brain tissue
  • Cerebrovascular fluid
  • Compartmental model
  • Compliance resistance
  • Intracranial pressure

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