Respiratory heat/water loss alone does not determine the severity of exercise-induced asthma

N. Noviski, E. Bar-Yishay, I. Gur, S. Godfrey

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Respiratory heat loss (RHL) or water loss (RWL) have been proposed as possible triggering factors in exercise and hyperventilation-induced asthma (EIA and HIA). It has recently been demonstrated that exercise intensity and climatic factors are both important in determining the severity of EIA. Eight young asthmatics performed both exercise and isocapnic hyperventilation (IHV) manoeuvres under identical climatic conditions, as part of our investigation of these interactive factors which determine the severity of the asthmatic response. It was found that, when challenged at low ventilatory levels, exercise produced a significantly attenuated asthmatic response compared to IHV. The fall in forced expired volume in 1 sec (ΔFEV1) following exercise was 15 ± 4% as compared with 27 ± 3% after IHV (p < 0.002). It is concluded that while the hypernoea in exercise may serve as a trigger, exercise per se introduces an additional factor which serves to limit the full response seen with IHV. This attenuated response is revealed at low ventilatory levels but is masked at high levels.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalEuropean Respiratory Journal
Volume1
Issue number3
StatePublished - 1 Jan 1988
Externally publishedYes

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