Respiratory Manifestations in Pediatric Patients With Interleukin 6 Receptor Deficiency

Noga Arwas; Eyal Kristal; Inbal Golan-Tripto; Aviv Goldbart; Guy Hazan; Amit Nahum; Shani Arotzker; Arnon Broides; Dvir Gatt

doi:10.1002/ppul.71174

Respiratory Manifestations in Pediatric Patients With Interleukin 6 Receptor Deficiency

Noga Arwas, Eyal Kristal, Inbal Golan-Tripto, Aviv Goldbart, Guy Hazan, Amit Nahum, Shani Arotzker, Arnon Broides, Dvir Gatt

Medical School for International Health

Research output: Contribution to journal › Letter › peer-review

Abstract

Interleukin-6 receptor (IL-6R) deficiency is a rare immunodeficiency marked by impaired IL-6 signaling, affecting the inflammatory response and respiratory health. In this report, pediatric patients with IL-6R deficiency presented with a spectrum of respiratory symptoms, from mild to severe infections, but did not commonly develop early bronchiectasis. Due to the absence of typical inflammatory markers in lung infections, routine imaging is advised to monitor for potential complications, even in the absence of overt clinical signs.

Original language	English
Article number	e71174
Journal	Pediatric Pulmonology
Volume	60
Issue number	6
DOIs	https://doi.org/10.1002/ppul.71174
State	Published - 1 Jun 2025

Keywords

chronic lung disease
interleukin 6 receptor
primary immunodeficiency
pulmonary

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ppul.71174

Cite this

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title = "Respiratory Manifestations in Pediatric Patients With Interleukin 6 Receptor Deficiency",

abstract = "Interleukin-6 receptor (IL-6R) deficiency is a rare immunodeficiency marked by impaired IL-6 signaling, affecting the inflammatory response and respiratory health. In this report, pediatric patients with IL-6R deficiency presented with a spectrum of respiratory symptoms, from mild to severe infections, but did not commonly develop early bronchiectasis. Due to the absence of typical inflammatory markers in lung infections, routine imaging is advised to monitor for potential complications, even in the absence of overt clinical signs.",

keywords = "chronic lung disease, interleukin 6 receptor, primary immunodeficiency, pulmonary",

author = "Noga Arwas and Eyal Kristal and Inbal Golan-Tripto and Aviv Goldbart and Guy Hazan and Amit Nahum and Shani Arotzker and Arnon Broides and Dvir Gatt",

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doi = "10.1002/ppul.71174",

language = "English",

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T1 - Respiratory Manifestations in Pediatric Patients With Interleukin 6 Receptor Deficiency

AU - Arwas, Noga

AU - Kristal, Eyal

AU - Golan-Tripto, Inbal

AU - Goldbart, Aviv

AU - Hazan, Guy

AU - Nahum, Amit

AU - Arotzker, Shani

AU - Broides, Arnon

AU - Gatt, Dvir

PY - 2025/6/1

Y1 - 2025/6/1

N2 - Interleukin-6 receptor (IL-6R) deficiency is a rare immunodeficiency marked by impaired IL-6 signaling, affecting the inflammatory response and respiratory health. In this report, pediatric patients with IL-6R deficiency presented with a spectrum of respiratory symptoms, from mild to severe infections, but did not commonly develop early bronchiectasis. Due to the absence of typical inflammatory markers in lung infections, routine imaging is advised to monitor for potential complications, even in the absence of overt clinical signs.

AB - Interleukin-6 receptor (IL-6R) deficiency is a rare immunodeficiency marked by impaired IL-6 signaling, affecting the inflammatory response and respiratory health. In this report, pediatric patients with IL-6R deficiency presented with a spectrum of respiratory symptoms, from mild to severe infections, but did not commonly develop early bronchiectasis. Due to the absence of typical inflammatory markers in lung infections, routine imaging is advised to monitor for potential complications, even in the absence of overt clinical signs.

KW - chronic lung disease

KW - interleukin 6 receptor

KW - primary immunodeficiency

KW - pulmonary

UR - https://www.scopus.com/pages/publications/105008737726

U2 - 10.1002/ppul.71174

DO - 10.1002/ppul.71174

M3 - Letter

C2 - 40536180

AN - SCOPUS:105008737726

SN - 8755-6863

VL - 60

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

IS - 6

M1 - e71174

ER -

Respiratory Manifestations in Pediatric Patients With Interleukin 6 Receptor Deficiency

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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