Respiratory tract colonization with ureaplasma urealyticum and bronchopulmonary dysplasia in neonates in Southern Israel

Shulamith Horowitz, Daniel Landau, Eric S. Shinwell, Ehud Zmora, Ron Dagan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Ureaplasma urealyticum has been recognized as an important potential pathogen in premature neonates. Reported rates of colonization of the respiratory tract vary. Data on neonatal ureaplasma colonization outside the United States and Western Europe are rare. Therefore we prospectively studied nasopharyngeal and endotracheal colonization in a cohort of 114 preterm and 100 full term infants within 48 hours of birth. The colonization rate was 24% in the premature infants and zero in the full term infants. Bronchopulmonary dysplasia developed in 19% of infants with nasopharyngeal Ureaplasma colonization and in 4.6% of non-colonized infants (P < 0.03). Bronchopulmonary dysplasia developed in 40% of intubated infants with positive endotracheal Ureaplasma cultures and only in 9.8% of infants with negative endotracheal cultures (P < 0.04). Thus Ureaplasma colonization of either the nasopharynx or the trachea was associated with an increased risk for the development of bronchopulmonary dysplasia (relative risk, 4.0 and 4.1, respectively).

Original languageEnglish
Pages (from-to)847-851
Number of pages5
JournalPediatric Infectious Disease Journal
Volume11
Issue number10
DOIs
StatePublished - 1 Jan 1992

Keywords

  • Bronchopulmonary dysplasia
  • Nasopharyngeal and endotracheal cultures
  • Premature neonates
  • Ureaplasma urealyticum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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