Response of vasculitic peripheral neuropathy to intravenous immunoglobulin

Yair Levy, Yosef Uziel, Giesele Zandman, Pnina Rotman, Hawared Amital, Yaniv Sherer, Pnina Langevitz, Boleck Goldman, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Peripheral neuropathy is a prominent feature of the systemic and secondary vasculitides. Usually, it responds to corticosteroids therapy, but in certain cases it may resist corticosteroid or immunosuppressive treatment, or both. The objective of this study is to present case reports of patients who exhibited various inflammatory diseases, accompanied with vasculitic peripheral neuropathies, for which intravenous immunoglobulin (IVIg) was used for treatment. The study included 10 patients with the following: Sjögren's syndrome (1), systemic lupus erythematosus (2), vaccination-induced vasculitis (1), Churg-Strauss vasculitis (1), mixed cryoglobulinemia (2), polyarteritis nodosa (1), sarcoidosis (1), and scleroderma (1). All developed vasculitic peripheral neuropathy and were treated with 1-13 cycles of high-dose IVIg (2 g/kg body weight). The patients were followed up for 1-5 years after this treatment. Results showed that in all but two patients (mixed cryoglobulinemia associated with hepatitis C and sarcoidosis), neuropathy improved or completely resolved after IVIg treatment. In conclusion, IVIg may be beneficial in cases of resistant vasculitic peripheral neuropathy. IVIg should probably be considered as a sole or adjuvant treatment in patients for whom conventional treatment is contraindicated, or for patients in whom conventional treatment has failed.

Original languageEnglish
Pages (from-to)779-786
Number of pages8
JournalAnnals of the New York Academy of Sciences
StatePublished - 1 Jan 2005
Externally publishedYes


  • Corticosteroids
  • Immunoglobulin
  • Peripheral neuropathy
  • Vasculitis

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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