TY - JOUR
T1 - Responsive polymer systems for controlled delivery of therapeutics
AU - Kost, Joseph
AU - Langer, Robert
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).
AB - The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).
UR - http://www.scopus.com/inward/record.url?scp=0026848935&partnerID=8YFLogxK
U2 - 10.1016/0167-7799(92)90194-Z
DO - 10.1016/0167-7799(92)90194-Z
M3 - Review article
AN - SCOPUS:0026848935
VL - 10
SP - 127
EP - 131
JO - Trends in Biotechnology
JF - Trends in Biotechnology
SN - 0167-7799
IS - C
ER -