Responsive polymer systems for controlled delivery of therapeutics

Joseph Kost, Robert Langer

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalTrends in Biotechnology
Volume10
Issue numberC
DOIs
StatePublished - 1 Jan 1992

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