Responsive polymer systems for controlled delivery of therapeutics

Joseph Kost; Robert Langer

doi:10.1016/0167-7799(92)90194-Z

Responsive polymer systems for controlled delivery of therapeutics

Joseph Kost, Robert Langer

Department of Chemical Engineering

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Trends in Biotechnology
Volume	10
Issue number	C
DOIs	https://doi.org/10.1016/0167-7799(92)90194-Z
State	Published - 1 Jan 1992

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/0167-7799(92)90194-Z

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AB - The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).

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Responsive polymer systems for controlled delivery of therapeutics

Abstract

ASJC Scopus subject areas

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