Responsive polymeric delivery systems

Joseph Kost, Robert Langer

Research output: Contribution to journalArticlepeer-review

543 Scopus citations


This paper discusses the state of the art in a relatively new approach in the field of controlled drug delivery-responsive polymeric drug delivery systems. Such systems are capable of adjusting drug release rates in response to a physiological need. The fundamental principles of externally and self-regulated delivery systems are examined. Special attention is paid to specific clinical settings such as diabetes, presenting the advantages and disadvantages of different approaches.

Original languageEnglish
Pages (from-to)125-148
Number of pages24
JournalAdvanced Drug Delivery Reviews
Issue number1-3
StatePublished - 1 Mar 2001


  • Controlled drug delivery
  • Controlled release
  • Environmentally sensitive polymer
  • Externally regulated drug delivery
  • Insulin delivery
  • Pulsatile drug delivery
  • Self-regulated drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science


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