Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures

O. Kofman, W. R. Sherman, V. Katz, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myo-inositol, artificial CSF or l-chiro-inositol. Lithium chloride, 3 meq/kg was administered intraperitoneally 20-24 h prior to the subcutaneous injection of pilocarpine 20 or 30 mg/kg. In both experiments, myo-inositol significantly prolonged the latency to the appearance of clonic seizures and lowered the pilocarpine seizure score. myo-Inositol prevented the development of clonic seizures in 50% of the rats receiving pilocarpine, 20 mg/kg. The levels of cortical myo-inositol in rats injected with myo-inositol were approximately double those of the CSF and l-chiro-inositol groups.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalPsychopharmacology
Volume110
Issue number1-2
DOIs
StatePublished - 1 Jan 1993

Keywords

  • Lithium
  • Lithium-pilocarpine seizures
  • Myo-inositol
  • Pilocarpine
  • l-Chiro-inositol

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures'. Together they form a unique fingerprint.

Cite this