Results of in vitro fertilization in women with antisperm antibodies in serum, cervical mucus, and follicular fluid

Gad Potashnik, Dita Kleinman, Vaclav Insler, Sarit Albotiano, Marek Glezerman, Israel Meizner

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    This study was undertaken to investigate the presence of antisperm antibodies (ASA) in serum, cervical mucus, and follicular fluid (FF) of women undergoing in vitro fertilization and embryo transfer (IVF-ET). IgG and IgA ASA directed mostly against sperm head were found at similar concentrations in serum, cervical mucus, and FF of 2 of 34 patients. Ninety-one percent fertilization and 100% cleavage rates, respectively, were observed in one of the two patients. No fertilization occurred in the second patient. In both women, in vitro sperm penetration tests revealed hostile mucus and repeated postcoital tests were poor. It is concluded that the sperm-cervical mucus penetration test and mucus ASA measurements are useful in establishing the diagnosis of immunological infertility.

    Original languageEnglish
    Pages (from-to)199-201
    Number of pages3
    JournalJournal of in Vitro Fertilization and Embryo Transfer
    Volume5
    Issue number4
    DOIs
    StatePublished - 1 Aug 1988

    Keywords

    • antisperm antibodies
    • cervical mucus
    • follicular fluid
    • in vitro fertilization
    • serum

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Embryology
    • Obstetrics and Gynecology
    • Developmental Biology

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