Results of multimodal therapy in Ewing's sarcoma: A retrospective analysis of 20 patients

Myriam Ben‐Arush, Abraham Kuten, Monique Perez‐Nahum, Yoram Cohen, Victor Bialik

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    1 Scopus citations

    Abstract

    A retrospective analysis was performed of 20 patients with Ewing's sarcoma treated by combined modality therapy, consisting of surgery, radiotherapy, and chemotherapy. Fourteen patients (70%) achieved complete remission and 5 patients (25%) were in partial remission at the end of treatment. One patient (5%) failed to respond to combined modality therapy. The overall 5 year actuarial survival was 64% and the disease free survival, 55%. Persistent or recurrent disease occurred in 8 patients (40%); one of them was salvaged by surgery and chemotherapy. Site and extent of primary lesion were prognosticators of patients' outcome. One patient developed radiation‐related‐sequelae. The efficacy of aggressive management consisting of wide surgery, radiotherapy and intermittent high dose chemotherapy is discussed.

    Original languageEnglish
    Pages (from-to)51-55
    Number of pages5
    JournalJournal of Surgical Oncology
    Volume48
    Issue number1
    DOIs
    StatePublished - 1 Jan 1991

    Keywords

    • VACA chemotherapy
    • central skeletal lesions
    • peripheral skeletal lesions
    • radiotherapy
    • surgery

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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