Results of multimodal therapy in Ewing's sarcoma: A retrospective analysis of 20 patients

Myriam Ben‐Arush; Abraham Kuten; Monique Perez‐Nahum; Yoram Cohen; Victor Bialik

doi:10.1002/jso.2930480110

Results of multimodal therapy in Ewing's sarcoma: A retrospective analysis of 20 patients

Myriam Ben‐Arush, Abraham Kuten, Monique Perez‐Nahum, Yoram Cohen, Victor Bialik

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Abstract

A retrospective analysis was performed of 20 patients with Ewing's sarcoma treated by combined modality therapy, consisting of surgery, radiotherapy, and chemotherapy. Fourteen patients (70%) achieved complete remission and 5 patients (25%) were in partial remission at the end of treatment. One patient (5%) failed to respond to combined modality therapy. The overall 5 year actuarial survival was 64% and the disease free survival, 55%. Persistent or recurrent disease occurred in 8 patients (40%); one of them was salvaged by surgery and chemotherapy. Site and extent of primary lesion were prognosticators of patients' outcome. One patient developed radiation‐related‐sequelae. The efficacy of aggressive management consisting of wide surgery, radiotherapy and intermittent high dose chemotherapy is discussed.

Original language	English
Pages (from-to)	51-55
Number of pages	5
Journal	Journal of Surgical Oncology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1002/jso.2930480110
State	Published - 1 Jan 1991

Keywords

VACA chemotherapy
central skeletal lesions
peripheral skeletal lesions
radiotherapy
surgery

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.2930480110

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abstract = "A retrospective analysis was performed of 20 patients with Ewing's sarcoma treated by combined modality therapy, consisting of surgery, radiotherapy, and chemotherapy. Fourteen patients (70%) achieved complete remission and 5 patients (25%) were in partial remission at the end of treatment. One patient (5%) failed to respond to combined modality therapy. The overall 5 year actuarial survival was 64% and the disease free survival, 55%. Persistent or recurrent disease occurred in 8 patients (40%); one of them was salvaged by surgery and chemotherapy. Site and extent of primary lesion were prognosticators of patients' outcome. One patient developed radiation‐related‐sequelae. The efficacy of aggressive management consisting of wide surgery, radiotherapy and intermittent high dose chemotherapy is discussed.",

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AU - Cohen, Yoram

AU - Bialik, Victor

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AB - A retrospective analysis was performed of 20 patients with Ewing's sarcoma treated by combined modality therapy, consisting of surgery, radiotherapy, and chemotherapy. Fourteen patients (70%) achieved complete remission and 5 patients (25%) were in partial remission at the end of treatment. One patient (5%) failed to respond to combined modality therapy. The overall 5 year actuarial survival was 64% and the disease free survival, 55%. Persistent or recurrent disease occurred in 8 patients (40%); one of them was salvaged by surgery and chemotherapy. Site and extent of primary lesion were prognosticators of patients' outcome. One patient developed radiation‐related‐sequelae. The efficacy of aggressive management consisting of wide surgery, radiotherapy and intermittent high dose chemotherapy is discussed.

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Results of multimodal therapy in Ewing's sarcoma: A retrospective analysis of 20 patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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